A Study to Test Whether Different Doses of Alteplase Help People With Severe Breathing Problems Because of COVID-19
Status:
Recruiting
Trial end date:
2022-08-15
Target enrollment:
Participant gender:
Summary
This is a study in adults with severe breathing problems because of COVID-19. People who are
in hospital on breathing support can participate in the study. The purpose of the study is to
find out whether a medicine called alteplase helps people get better faster.
The study has 2 parts. In the first part, participants are put into 3 groups by chance.
Participants in 2 of the groups get 2 different doses of alteplase, in addition to standard
treatment.
Participants in the third group get standard treatment. In the second part of the study,
participants are put into 2 groups by chance. One group gets alteplase and standard
treatment. The other group gets only standard treatment. Alteplase is given as an infusion
into a vein. In both study parts, treatments are given for 5 days. Doctors monitor patients
and check whether their breathing problems improve. They compare results between the groups
after 1 month.
Participants are in the study for 3 months.