A Study to See if Certain Antioxidants and Vitamins Will Keep Lactate Levels Down in Patients Taking Anti-HIV Drugs
Status:
Withdrawn
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
The purpose of this study is to see if certain vitamins (C, E, B1, and B2) can keep lactate
levels from becoming too high in patients who are taking nucleoside reverse transcriptase
inhibitor (NRTI) anti-HIV drugs.
Some patients taking anti-HIV drugs develop hyperlactatemia. Hyperlactatemia is a condition
in which lactate (a natural substance normally present in the body) levels are too high. Too
much lactate in the body can lead to serious health problems. When patients suffer from
hyperlactatemia while taking anti-HIV drugs, most doctors temporarily stop the drugs.
Patients then restart the anti-HIV drugs when their lactate levels return to normal. If
patients restart the same drugs they were taking when they developed hyperlactatemia, there
is a risk that they may develop high lactate levels again. This study wants to find out if
taking antioxidants (substances that reduce tissue damage due to oxygen radicals) and certain
B vitamins may help prevent patients from developing hyperlactatemia when they restart the
same anti-HIV drugs.
Phase:
N/A
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Treatments:
Antioxidants Ascorbic Acid Riboflavin Thiamine Vitamin E Vitamins