Overview

A Study to Learn About the ARV-471 (PF-07850327) in People With ER+/HER2- Locally Advanced or Metastatic Breast Cancer (BC)

Status:
Not yet recruiting
Trial end date:
2023-04-19
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this clinical trial is to learn about the safety, tolerability, Pharmacokinetics (PK), and preliminary efficacy of ARV-471 as monotherapy in Japanese participants with ER+/HER2- locally advanced or metastatic breast cancer (mBC).
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Pfizer
Collaborator:
Arvinas Androgen Receptor, Inc.
Criteria
Inclusion Criteria:

1. Participants (women and men) at least 20 years of age at the time of signing the
informed consent.

2. Histological or cytological diagnosis of ER+/HER2- advanced breast cancer that is
metastatic, recurrent, or locally advanced unresectable breast cancer.

3. Participants who are resistant to standard therapy or for which no standard therapy is
available or have received.

4. Capable of giving signed informed consent, which includes compliance with the
requirements and restrictions listed in the Infromed Consent Document (ICD) and in
this protocol.

5. Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1.

6. Adequate Bone Marrow or Coagulation Function.

7. Adequate Renal Function, defined as an estimated creatinine clearance ≥60 mL/min as
calculated using the method standard for the institution.

8. Adequate Liver Function.

9. Participants with brain metastases must meet all the specified conditions.

10. Resolution of acute effects of any prior therapy to either baseline severity or CTCAE
version 5.0 Grade ≤1.

Exclusion Criteria:

1. Participants with any other active malignancy within 3 years prior to enrollment,
except for adequately treated basal cell or squamous cell skin cancer, or carcinoma in
situ of the cervix, Bowen's disease.

2. Participants sustaining major surgery defined as a complex procedure performed under
regional or general anesthesia with a recovery period of at least 4 weeks prior to
study enrollment.

3. Known or suspected hypersensitivity or severe allergy to active ingredient/excipients
of ARV-471.

4. Other medical or psychiatric condition including recent (within the past year) or
active suicidal ideation/behavior or laboratory abnormality that may increase the risk
of study participation or, in the investigator's judgment, make the participant
inappropriate for the study.

5. Radiation therapy within 4 weeks of first dose of study drug or prior irradiation to
>25% of the bone marrow. Palliative radiation for the alleviation of pain due to bone
metastasis will be allowed during the study.

6. Concurrent administration of medications, foods or herbal supplements that are strong
inhibitors or inducers of cytochrome CYP3A4, substrates of P-gp, sensitive substrates
of CYP2B6, proton pump inhibitors, or medicines known risk of causing Torsade de
Pointes. Prior use of strong CYP3A inhibitors must be stopped 7 days and strong CYP3A
inducers must be stopped 14 days before randomization.

7. Prior treatment with ARV-471.

8. Systemic anticancer therapy chemotherapy or endocrine therapy within 14 days prior to
study entry (6 weeks for mitomycin C or nitrosoureas). If the last immediate
anticancer treatment contained an antibody-based agent(s) (approved or
investigational), then an interval of 28 days or 5 half-lives (whichever is shorter)
of the agent(s) prior to receiving the study intervention treatment is required.

9. Participants who have initiated therapy with bone-modifying agents (bisphosphonates,
denosumab, or similar) within 14 days of enrollment.

10. Previous high-dose chemotherapy requiring stem cell rescue.

11. Participation in other studies involving investigational drug(s) within 4 weeks prior
to study entry. A participant may be eligible even if they are in the follow-up phase
of an investigational study as long as they haven't received treatment in the study
for 5 half lives of the agents.

12. Serum pregnancy test (for females of childbearing potential) positive at screening
and/or a breastfeeding participant.

13. Participants with active, uncontrolled bacterial, fungal, or viral infection,
including (but not limited to) Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), and
known Human Immunodeficiency Virus (HIV) or Acquired Immunodeficiency Syndrome
(AIDS)-related illness.

14. Baseline standard 12 lead electrocardiogram (ECG) that demonstrates clinically
relevant abnormalities that may affect participant safety or interpretation of study
results.

15. Any of the following in the previous 12 months: myocardial infarction, long QT
syndrome, Torsade de Pointes, clinically important atrial or ventricular arrhythmias,
serious conduction system abnormalities, unstable angina, coronary/peripheral artery
bypass graft, symptomatic CHF, New York Heart Association class III or IV,
cerebrovascular accident, transient ischemic attack, symptomatic pulmonary embolism,
and/or other clinical significant episode of thrombo-embolic disease. Ongoing cardiac
dysrhythmias of NCI CTCAE Grade ≥2, atrial fibrillation of any grade . If a
participant has a cardiac rhythm device/pacemaker placed and QTcF >470 ms, the
participant may be considered eligible. Participants with cardiac rhythm
device/pacemaker must be discussed in detail with the sponsor to judge eligibility.

16. History of symptomatic cardiac valve disease.

17. Active inflammatory gastrointestinal disease, chronic diarrhea, known diverticular
disease or previous gastric resection or lap band surgery.