Overview

A Study to Investigate the Interaction Between Givosiran and a 5-probe Drug Cocktail in Patients With Acute Intermittent Porphyria (AIP)

Status:
Completed

Trial end date:
2019-01-10

Target enrollment:

Participant gender:

Summary

The purpose of this study is to evaluate the effect of givosiran on the pharmacokinetics of the 5-probe cocktail of midazolam, caffeine, losartan, omeprazole, and dextromethorphan, and their metabolites, in asymptomatic patients with Acute Intermittent Porphyria.

Phase:

Phase 1

Details

Lead Sponsor:

Alnylam Pharmaceuticals

Treatments:

Dextromethorphan
Omeprazole