Overview

A Study to Investigate the Drug-drug Interactions (DDIs) of SKLB1028 With Itraconazole, Gemfibrozil or Rifampicin in Healthy Subjects

Status:
Active, not recruiting
Trial end date:
2021-11-01
Target enrollment:
0
Participant gender:
Male
Summary
This is a three-part, single-center, open-label phase I clinical study to characterize the DDIs potential of SKLB1028 with Itraconazole, Gemfibrozil or Rifampicin in healthy subjects. This study also aims to evaluate the safety and tolerability of SKLB1028 in the presence of Itraconazole, Gemfibrozil or Rifampicin.
Phase:
Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Treatments:
Gemfibrozil
Itraconazole
Rifampin
Criteria
Inclusion Criteria:

-

Healthy subjects:

1. Voluntarily sign the informed consent form, understand the trial procedures, and be
willing to comply with all trial procedures and restrictions;

2. 18 ≤ age ≤45, male;

3. Subjects with weight ≥50.0 kg and body mass index (BMI) 19-26 kg/m^2 (inclusive);

4. Subjects are willing to use effective contraceptives and not allowed to donate sperm
from screening to the 6 months after the last dose administration unless permanent
contraception has been taken, such as vasectomy.

5. Ability to communicate well with researchers, and be willing to comply with all trial
requirements.

Exclusion Criteria:

1. Allergic constitution, including a history of allergy to any of the study drugs or
other similarly structured drugs;

2. Previous or current severe diseases, such as cardiovascular, respiratory,
gastrointestinal, endocrine, hematological, psychiatric/neurological systems diseases,
or any other disease that can interfere with the results of the study;

3. Subjects who have previously undergone surgery that may affect the absorption,
distribution, metabolism, or excretion of the drug (e.g., subtotal gastrectomy), or
who have a scheduled surgical plan during the study period;

4. Use of any strong inhibitors or inducers of CYP3A4, CYP2C8 or P-gp within 2 weeks
prior to screening;

5. Use of any prescription drug, over-the-counter drug, herbal medicine or health
products within 2 weeks prior to screening;

6. History of drug abuse within 1 year prior to screening, or positive urine drug screen
at screening;

7. Smoking more than 5 cigarettes per day within 6 months prior to screening;

8. Average daily intake of alcohol more than 14 units (14 units ≈285 mL of beer, or 25 mL
of liquor, or 150 mL of wine) within 4 weeks prior to screening, or a positive ethanol
breath test at screening;

9. Consumption of grapefruit juice, methylxanthine-rich food or beverage (such as coffee,
tea, cola, chocolate, energy drinks) within 48 h before the administration, or those
who have had strenuous exercise, or have other factors affecting absorption,
distribution, metabolism, excretion, etc of the drug;

10. Participation in another clinical trial within 3 months before screening (whichever is
administrated);

11. Blood donation (or blood loss) ≥200 mL within 4 weeks prior to the screening, or who
have a blood donation plan during the entire study or within 1 months after the study;

12. Any abnormalities of clinical significance in physical examination, vital signs,
clinical laboratory tests (routine blood test, blood biochemistry, routine urine test,
coagulation function), anteroposterior chest radiograph or chest CT scan;

13. Abnormalities of clinical significance in 12-lead ECG examination (such as
tachycardia/bradycardia in need of medical treatment, II-III degree atrioventricular
block, QTcF>450 ms or any other clinically significant abnormalities );

14. Any positive test result of hepatitis B surface antigen or hepatitis C virus antibody,
or subjects with a history of hepatitis B;

15. Any positive test result of anti-human immunodeficiency virus antibody or
anti-Treponema pallidum specific antibody;

16. Any condition that, in the opinion of the Investigator, may prevent the subject from
completing the study or poses a significant risk to the subject.