A Study to Evaluate the Use of Memantine In Combination With Anti-HIV Drugs to Treat AIDS Dementia Complex (ADC)
Status:
Completed
Trial end date:
2001-07-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine the safety and effectiveness of memantine, an
experimental drug, in improving AIDS dementia complex (ADC).
The symptoms of ADC can be improved with zidovudine (ZDV). However, ZDV therapy has been
associated with significant toxicities, and the effectiveness of ZDV seems to decrease during
the second and third years of therapy. The effectiveness of other antiretroviral drugs as
treatment for ADC is not known, so it is important to explore alternative therapies.
Phase:
Phase 2
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)