Overview
A Study to Evaluate the Impact of Lactobacillus Rhamnosus GG on Proton Pump Inhibitor-Induced Gut Dysbiosis
Status:
Not yet recruiting
Not yet recruiting
Trial end date:
2024-01-01
2024-01-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
The purpose of this study is to investigate the impact of the probiotic Lactobacillus rhamnosus (LGG) on proton pump inhibitor (PPI)-induced changes to the microbes that live in the gastrointestinal tract and are passed out in the stool. PPI medicines reduce stomach acid and are commonly used to treat acid reflux disease.Phase:
N/AAccepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
Mayo ClinicTreatments:
Omeprazole
Criteria
Inclusion Criteria:- Individuals on an unrestricted regular diet with no dietary restrictions (vegan, low
FODMAP, gluten free, dairy-free etc) or other fad diets (e.g., keto, intermittent
fasting, etc.).
- Healthy subjects will be screened for current or chronic GI symptoms using a 16-item
questionnaire.
- Only those with an absence of symptoms will eligible to participate.
Exclusion Criteria:
- For healthy volunteers, will include prior surgery altering the esophagus, stomach,
and intestine (except appendectomy).
- Chronic daily use of medications affecting GI secretion or motor function.
- The presence of any GI-motility affecting systemic diseases or untreated psychiatric
disease.
- Pregnancy.