A Study to Evaluate the Effects of Tedizolid Phosphate on the Pharmacokinetics and Safety of Midazolam and Rosuvastatin (MK-1986-004)

• Status: Completed
• Trial end date: 2015-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to assess the effect of steady-state tedizolid phosphate on the single-dose pharmacokinetics of midazolam and rosuvastatin in healthy, adult participants.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Merck Sharp & Dohme Corp.
• Treatments: Midazolam; Oxazolidinones; Rosuvastatin Calcium; Tedizolid; Tedizolid phosphate; Torezolid; Torezolid phosphate

Criteria

Inclusion Criteria:

• healthy, adult males or females (women of non-childbearing potential)

• continuous non-smokers who have not used nicotine-containing products for the previous 3 months

Exclusion Criteria:

• mentally or legally incapacitated or has significant emotional problems

• history or presence of clinically significant medical or psychiatric condition or disease

• history or presence of alcoholism or drug abuse within the past 2 years

• female participants who are pregnant, lactating, or of childbearing potential

• donated blood or had significant blood loss within 56 days prior to first dose of study drug

• plasma donation within 7 days prior to first dose of study drug