A Study to Evaluate the Effects of Lithium, Valproic Acid, and Lamotrigine on the Pharmacokinetics of KarXT and Effects of KarXT on the Pharmacokinetics of Lithium, Valproic Acid, and Lamotrigine in Healthy Participants

• Status: RECRUITING
• Trial end date: 2026-01-18

Summary

The purpose of this study is to evaluate the effects of lithium, valproic acid, and lamotrigine on the single-dose pharmacokinetics (PK) of KarXT and the effect of KarXT on the single-dose PK of lithium, valproic acid, and lamotrigine in healthy participants.

• Phase: PHASE1

Details

• Lead Sponsor: Karuna Therapeutics
• Treatments: Lamotrigine; Lithium; trospium chloride; Valproic Acid; xanomeline