Overview

A Study to Evaluate the Effect of a Contraceptive Vaginal Ring Delivering Ulipristal Acetate Combined With a Single or Repeated Levonorgestrel on Inhibition of Ovulation, Endometrial Changes and Bleeding Patterns in Normal Cycling Women

Status:
Unknown status
Trial end date:
2017-12-31
Target enrollment:
0
Participant gender:
Female
Summary
The purpose of this study is to determine the effect of a contraceptive vaginal ring on inhibition of ovulation, endometrial changes and bleeding patterns in normal cycling women.
Phase:
Phase 1/Phase 2
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Population Council
Treatments:
Contraceptive Agents
Levonorgestrel
Ulipristal acetate
Criteria
Inclusion Criteria:

- Not at risk for pregnancy based on one of the following: a. subject has undergone
sterilization; b. subject is monogamous and her male partner has undergone
sterilization

- Have regular menstrual cycles of 25-35 days duration

- Have an intact uterus and both ovaries

- Will be able to comply with the protocol

- Capable of giving informed consent

Exclusion Criteria:

- Women participating in another clinical trial

- Women not living in the catchment area of the clinic

- Known hypersensitivity to progestins or antiprogestins

- Known hypersensitivity to silicone rubber

- Any chronic disease

- All contraindications to oral contraceptive use, including: a. Thrombophlebitis or
thromboembolic disorders; b. Past history of deep vein thrombophlebitis or
thromboembolic disorders; c. Past or current cerebrovascular or coronary artery
disease; d. Migraine with focal aura; e. Known or suspected carcinoma of the breast;
f. Carcinoma of the endometrium or other known or suspected estrogen-dependent
neoplasia; g. Undiagnosed abnormal genital bleeding; h. Cholestatic jaundice of
pregnancy or jaundice with prior pill use; i. Hepatic adenomas or carcinomas; j. Known
or suspected pregnancy

- Desire to get pregnant during the study (through the use of reproductive technology
for sterilized women or vasectomy reversal for sterilized partners)

- Breastfeeding

- Undiagnosed vaginal discharge or vaginal lesions or abnormalities

- Women with a current abnormal Pap: In accordance with the Bethesda system of
classification: smear suggestive of high-grade pre-cancerous lesion(s), including
HGSIL, are excluded; Women with LGSIL or ASCUS/high-risk HPV positive may participate
if further evaluated with colposcopy and biopsy and no evidence of a lesion with a
severity > CIN I is present and/or endocervical curettage is negative; Women with a
biopsy finding of CIN I should have follow up for this finding per standard of care;
women are excluded it treatment is indicated.

- Known benign or malignant liver tumors; known active liver disease

- Cancer (past history of any carcinoma or sarcoma)

- Medically diagnosed severe depression currently or in the past

- Known or suspected alcoholism or drug abuse

- Abnormal serum fasting clinical chemistry values

- Women with known abnormal thyroid status

- Women with known impaired hypothalamic-pituitary-adrenal reserve

- Average diastolic BP > 85 mm or systolic BP >135 mm Hg after 5-10 minutes rest

- Body mass index (BMI) > 30.0 (or ≤18)

- Smoking in women who will be 35 years during the course of the trial; women < 35 years
who smoke greater than 15 cigarettes per day must be evaluated by the PI for inclusion
based on risk factors that would increase their risk for CVD and thromboembolism, e.g.
lipid levels, glucose level, BP, BMI, family history of CVD at a young age.

- Women with severe cystoceles or rectoceles

- Use within the past 2 months of any implanted hormonal contraceptives including Mirena
[progestin containing intrauterine system (IUS)] or Norplant (subdermal implant
delivering LNG). NOTE: Removal of implanted hormonal contraceptives must have been for
personal reasons unrelated to the purpose of enrollment in this study.

- Current use of a non-hormone containing IUD. NOTE: Removal of an IUD must have been
for personal reasons unrelated to the purpose of enrollment in this study.

- Use of injectable contraceptives during the previous 3 months (e.g. Cyclofem) or 6
months (e.g. DMPA).

- Women who do not have at least two progesterone measurements during the control cycle
of ≥10nmol/L will be excluded from further participation in the study (See Section
13.4.1)