A Study to Evaluate the Effect of Vitamin D Supplementation on Insulin Sensitivity and Secretion

• Status: Completed
• Trial end date: 2006-05-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of the study is to evaluate the change in insulin sensitivity and secretion indices (early markers for development of diabetes) after 4 weeks of a megadose of Vitamin D. This will also help to calculate sample size for and choose an appropriate index for a larger randomized control trial which may be required subsequently.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Sitaram Bhartia Institute of Science and Research
• Treatments: Ergocalciferols; Insulin; Insulin, Globin Zinc; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Male

• ≥30 years of age

• Waist circumference ≥80 cm

Exclusion Criteria:

• Diabetic- Fasting Blood Sugar >126 mg/dl or on anti-diabetic medication

• BP>140/90 or on anti-hypertensive medication

• Receiving Vitamin D or calcium supplementation

• Chronic disease-renal/hepatic/malignancy/gastrointestinal

• On any medication within the last one month which could potentially influence insulin secretion, insulin sensitivity, Vitamin D or Calcium metabolism

• Febrile illness or infective morbidity in the past 10 days