A Study to Evaluate the Effect of Single Doses of Drug A (Lamotrigine) and Drug B (Vofopitant) Alone and in Combination on Resting Motor Threshold in Healthy Subjects

• Status: Terminated
• Trial end date: 2010-06-10
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to investigate the effect of drug A on its own and when it is given in combination with drug B on markers of brain activity. The study will

1. Assess the effects of drug A and drug B on muscle movement after brain stimulation;

2. Examine how the body handles (absorbs, distributes, breaks down and gets rid of) drug A and drug B when given in combination;

3. Examine the safety of drug A and drug B when given together.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: GlaxoSmithKline
• Treatments: Anticonvulsants; Lamotrigine; Vofopitant

Criteria

Inclusion Criteria:

• Healthy subject

• Male aged 18-65

• Greater than 50kg weight

• BMI 19-29.9 kg/m2

Exclusion Criteria:

• Positive drug/alcohol screen

• Positive HIV antibody

• History of drug dependence

• History of neurological disease

• Pacemaker

• Smoker