A Study to Evaluate the Abuse Potential of Oxymorphone Compared to Other Mu Opioid Agonists.
Status:
Recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
Significant public health concerns have arisen from the intravenous misuse of oxymorphone, a
potent mu opioid pain medication. However, little is known about its abuse potential relative
to other mu opioid analgesics. The present study is designed to examine the abuse liability
of intravenous oxymorphone compared to other mu opioid agonists (oxycodone, morphine, and
hydromorphone) among physically dependent opioid abusers. This inpatient study examines the
reinforcing effects of oxymorphone and other mu opioid agonists using drug
self-administration procedures, and assessments of subjective effects.