Overview

A Study to Evaluate CBP-201 in Adult Patients With Chronic Rhinosinusitis With Nasal Polyps

Status:
Recruiting
Trial end date:
2023-01-01
Target enrollment:
0
Participant gender:
All
Summary
This study will evaluate the effect of CBP-201 in adult patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP).
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Suzhou Connect Biopharmaceuticals, Ltd.
Criteria
Inclusion Criteria:

1. Female and male patients aged ≥ 18 and ≤ 75 years at the time of screening.

2. Patients who are diagnosed with chronic rhinosinusitis with bilateral polyps despite
treatment with systemic corticosteroid within the past 2 years and/or medical
contraindication/intolerance to systemic corticosteroids. The polyps have a minimum
bilateral NPS of 5 out of a maximum score of 8 with at least a score of 2 for each
nostril at screening and baseline evaluated by endoscopy.

3. Nasal congestion/blockade/obstruction with moderate or severe symptom severity (Nasal
Congestion Score of > 2) at screening and a weekly average severity of > 1 at time of
randomization.

4. Patients using a documented stable dose of nasal mometasone at least 200 mcg/day, or
an equivalent daily dose of another INCS, for at least 28 days before randomization
and willing to continue the dose for the duration of the study. Note: For patients who
are using an alternative INCS product other than mometasone furoate nasal spray (MFNS)
prior to the screening visit, the investigator must switch the patient to MFNS at V1.

5. Patients willing to enter Patient Diary daily symptom assessments and maintain stable
dosing with MFNS with a compliance of at least 70% in the 7 days preceding
randomization. Note: Patients must use nasal mometasone at least 200 mcg/day, or
equivalent, for at least 28 days before randomization, which can include days prior to
screening with supportive documentation. Run-in can be 7-31 days with the compliance
determined in the week prior to dosing.

6. Male patients who are non-sterilized and sexually active with a female partner of
childbearing potential agree to use highly effective contraception from randomization
until 8 weeks after last dose.

7. Female patients of childbearing potential who are sexually active with a nonsterilized
male partner should have a confirmed negative serum beta-human chorionic gonadotropin
test at Visit 1 and agrees to use highly effective contraception from signing of
informed consent throughout the duration of the study and for 8 weeks after last dose.

8. Patient is able to understand and willing to sign the informed consent form (ICF)
prior to any study related procedures being performed.

9. Willing and able to comply with all study visits and study-related procedures, in the
opinion of the Investigator.

Exclusion Criteria:

-

A patient who meets any of the following criteria will be ineligible to participate in
this study:

10. Patients unable to use MFNS.

11. Patients who are taking or have taken the following prohibited therapies as specified:

1. Systemic steroids within 28 days prior to screening,

2. Other nonbiologic investigational drugs within 60 days (or 5 half-lives,
whichever is longer) of screening,

3. Intranasal corticosteroid drops or corticosteroid-administering devices (eg,
OptiNose device or stents) within 28 days prior to screening,

4. Non-steroidal immunosuppressants (eg, cyclosporine, methotrexate, azathioprine,
mycophenolate, sirolimus, tacrolimus) within 60 days or 5 half-lives, whichever
is longer, of screening,

5. Any monoclonal antibody therapy (eg, benralizumab, mepolizumab, omalizumab,
resilizumab, dupilumab) or investigational biologic drug for asthma or other
diseases within 60 days or 5 half-lives, whichever is longer, of screening,

6. Leukotriene antagonists/modifiers within 7 days prior to screening for patients
who were not on continuous treatment for ≥ 30 days prior to screening,

7. Allergen immunotherapy for patients who were not on maintenance treatment for at
least 90 days prior to screening

12. Patients who did not respond favorably to previous dupilumab treatment (eg, therapy
failure or patient experienced an adverse reaction to treatment).

13. Patients who have undergone any nasal surgery (including polypectomy) within 6 months
before screening; or have a history of sinus or nasal surgery modifying the structure
of the nose such that assessment of NPS is not possible, or have had uncontrolled
epistaxis requiring surgical or procedural intervention, including nasal packing.

14. Patients with conditions/concomitant diseases making them non evaluable at screening
or for the primary efficacy endpoint such as: antrochoanal polyps, nasal septal
deviation that would occlude at least 1 nostril, acute sinusitis, nasal infection or
upper respiratory infection at screening or within 2 weeks before screening, ongoing
rhinitis medicamentosa; known or suspected diagnosis of cystic fibrosis; chronic
granulomatous disease and granulomatous vasculitis, granulomatosis with polyangiitis
(Wegener's Granulomatosis), eosinophilic granulomatous with polyangiitis
(Churg-Strauss syndrome), Young's syndrome, primary dyskinetic ciliary syndromes (eg,
Kartagener's syndrome) or other dyskinetic ciliary syndromes.

15. Signs or a CT scan suggestive of Allergic Fungal Rhinosinusitis.

16. Patients with co-morbid asthma are excluded if:

1. Forced Expiratory Volume in 1 second (FEV1) ≤ 50% of normal predicted value OR

2. An exacerbation within 90 days prior screening that required hospitalization (>
24 hours) OR

3. Are on a daily dose of inhaled corticosteroids (ICS) higher than 1000 mcg
fluticasone or the equivalent.

17. Known or suspected history of immunosuppression, including history of invasive
opportunistic infections, such as aspergillosis, coccidioidomycosis, histoplasmosis,
human immunodeficiency virus (HIV), listeriosis, pneumocystosis, or tuberculosis,
despite infection resolution; or unusually frequent, recurrent or prolonged
infections. Tuberculosis testing would be performed on a country-by-country basis
according to local guidelines if required by regulatory authorities or ethics
committees.

18. Patients who have active Hepatitis B, Hepatitis C or HIV infections as determined by
positive results at Screening for hepatitis B surface antigen (HBsAg) or hepatitis B
core antibody (HBcAb); or hepatitis C (HCV) antibody; or positive HIV serology. Note:
Patients who test positive for HBvAb, negative for HBsAg and subsequently confirmed
positive for HBsAb, indicating resolved natural infection (confirmed by negative
HBV-DNA), may participate. Patients with positive HCV may participate if subsequent
viral load is confirmed negative.

19. A helminth parasitic infection diagnosed within 24 weeks prior to the date of informed
consent that has not been treated, or has failed to respond to, standard of care
therapy.

20. Evidence of infection requiring treatment with systemic antibacterials, antivirals,
antifungals, antiparasitics, or antiprotozoals within 7 days before baseline, or viral
infections within 14 days before screening that may not have received antiviral
treatment.

21. Live, attenuated vaccinations within 28 days prior to screening or planned live,
attenuated vaccinations during the study.

22. Pregnant or intent to become pregnant during the study, or breast-feeding women.

23. Any disorder, including, but not limited to, cardiovascular, gastrointestinal,
hepatic, renal, neurological, musculoskeletal, infectious, endocrine, metabolic,
haematological, psychiatric, or major physical impairment that is not stable in the
opinion of the investigator and may affect the safety of the patient throughout the
study, or influence the findings of the studies or their interpretations, or impede
the patient's ability to complete the entire duration of study.

24. Any clinically significant abnormal findings in physical examination, vital signs,
safety lab tests during screening/run-in period, which in the opinion of the
investigator, may put the patient at risk because of their participation in the study,
or may influence the results of the study, or the patient's ability to complete entire
duration of the study.

25. Have any of the following laboratory abnormalities at Screening:

1. Eosinophils >1500 cells/mm3 (or 1.5 x 10E9/L)

2. Platelets <100000 cells/mm3 (or 100 x 10E9/L)

3. Creatine phosphokinase (CPK) > 10 upper limit of normal (ULN)

4. Alanine aminotransferase (ALT) > 2.5 times the ULN

5. Aspartate aminotransferase (AST) ≥ 2.5 times the ULN

6. Bilirubin ≥ 2 times the ULN

26. History of alcohol or drug abuse within 12 months prior to the date informed consent.

27. An allergy to L-histidine, trehalose or Tween (polysorbate) 80 or a history of a
systemic hypersensitivity reaction, other than localized injection site reaction, to
any biologic drug.

28. Plans to undergo any surgical procedure requiring general anesthesia during the study.

29. History of cancer: Patients who have had basal cell carcinoma, localized squamous cell
carcinoma of the skin, or in situ carcinoma of the cervix are eligible provided that
the patient is in remission and curative therapy was completed at least 12 months
prior to the date informed consent. Note: Patients who have had other malignancies are
eligible provided that the patient is in remission and curative therapy was completed
at least 5 years prior to the date of informed consent.