A Study to Evaluate Bioavailability and Food Effect of Selumetinib (AZD6244) in Healthy Male Participants
Status:
Completed
Trial end date:
2018-10-21
Target enrollment:
Participant gender:
Summary
This study will evaluate bioavailability and food effect of selumetinib (AZD6244) in healthy
male participants. A total of 24 healthy male participants will be included to ensure at
least 20 evaluable participants. The study is divided in 2 study parts; the same participants
will participate in both parts of the study. Part 1 of the study is to investigate the
pharmacokinetics (PK) of the selumetinib granule compared to the PK of selumetinib capsule,
when administered with water under the fasted conditions. Part 2 of the study is to
investigate the PK of selumetinib granule and capsule under fed conditions. Participants will
also receive a single 500 mg dose of acetaminophen at the same time as selumetinib
administration.