A Study to Determine the Effectiveness and Tolerability of MK8141 in Patients With High Blood Pressure (MK-8141-006)

• Status: Completed
• Trial end date: 2008-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will evaluate the effectiveness and tolerability of MK8141 in lowering blood pressure in patients who have hypertension (high blood pressure).

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Merck Sharp & Dohme Corp.
• Collaborator: Actelion
• Treatments: Enalapril; Enalaprilat

Criteria

Inclusion Criteria:

• You are 35 to 65 years of age

• In the past 14 days you have not been treated for hypertension

• In the past 14 days you have not taken more than 2 medications to treat high blood pressure

• You are a woman who is not able to have children or do not use birth control

Exclusion Criteria:

• You are taking more than 2 medications to treat high blood pressure

• You have a history of a stroke, transient ischemic attack (TIA), heart attack, congestive heart failure, coronary artery bypass surgery

• You have Type 1 or 2 diabetes mellitus

• You have an active liver disease, gallbladder disease, or bowel disease

• You are HIV positive

• You have certain types of cancer

• You abuse drug or alcohol

• You have participated in another clinical study in last 4 weeks