A Study to Assess the Safety, Efficacy, and Pharmacokinetics of Multiple Doses of ION224
Status:
Recruiting
Trial end date:
2023-09-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to assess the effect of multiple ION224 doses when administered
by subcutaneous (SC) injection for 49 weeks (end of the treatment [EOT]) on non-alcoholic
steatohepatitis (NASH) histologic improvement and to assess the effect on liver steatosis by
magnetic resonance imaging-determined proton density fat fraction (MRI-PDFF), additional
changes in NASH histologic features, liver biochemistry tests, and plasma lipid profile.