Overview
A Study to Assess Efficacy and Safety of SER-287 in Adults With Active Mild-to-Moderate Ulcerative Colitis
Status:
Terminated
Terminated
Trial end date:
2021-10-13
2021-10-13
Target enrollment:
0
0
Participant gender:
All
All
Summary
A Randomized, Double-Blind, Placebo-Controlled, Multiple Dose, Multicenter Study to Assess Efficacy and Safety of SER-287 in Adults with Active Mild-to-Moderate Ulcerative ColitisPhase:
Phase 2Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Seres Therapeutics, Inc.Treatments:
Vancomycin
Criteria
Inclusion Criteria:- Documented diagnosis of UC at least three months prior to screening, and with a
minimum disease extent of 15 cm from the anal verge
- Active mild-to-moderate UC
- Inadequate response to, loss of response to, or intolerance of, at least one of the
following conventional therapies: 5-ASA compounds, corticosteroids, 6-mercaptopurine
(6-MP) or azathioprine (AZA), anti-TNFα, anti-integrin or tofacitinib
Exclusion Criteria:
- Known history of Crohn's disease
- No previous history of treatment for UC (treatment-naïve)
- Subjects on steroid medication who are unable to have steroids tapered and be
completely off steroids at least two weeks prior to screening
- Unable to stop steroid enemas or suppositories, or 5-ASA enemas or suppositories, at
least two weeks prior to screening
- Subjects who have received any investigational or approved biologic therapy within
eight weeks or five half-lives prior to screening (whichever is longer)
- Subjects who have received any investigational or approved non-biologic therapy,
except for those specifically listed in the Permitted Concomitant Medications, for the
treatment of underlying disease, within 30 days or five half-lives prior to screening
(whichever is longer)
- Major gastrointestinal surgery (not including appendectomy or cholecystectomy) within
two months before screening, or any history of total colectomy