A Study on the Effects of a Single Dose of Prednisone on Biomarkers of Allergen Responses in Asthmatics (MK-0000-175)
Status:
Completed
Trial end date:
2011-05-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to evaluate the relationship between upper and lower airway
allergen-induced cytokine responses in mild asthmatics by attempting to demonstrate the
following: 1) a positive correlation between allergen-induced Type 2 T-helper cell (Th2)
cytokines (interleukins 5 and 13) in sputum and nasal exudates; and 2) a positive correlation
between effects of prednisone versus placebo on Th2 cytokines in sputum and nasal exudates.