A Study on the Effects of Midazolam on Delirium After Sevoflurane Anesthesia in Pediatric Strabismus Surgery
Status:
Completed
Trial end date:
2012-11-01
Target enrollment:
Participant gender:
Summary
Sevoflurane with its rapid induction and emergence, hemodynamic stability, and nonirritating
airway properties, has acquired widespread acceptance in children. However, sevoflurane has
been reported to be associated with emergence agitation in children, with a reported
incidence of up to 80%.
The purpose of this study is to verify that the prophylactic use of midazolam, which is a
GABA A receptor inhibitor, given five minutes before the end of strabismus surgery reduces
the incidence of emergence agitation after sevoflurane anesthesia in children.
Simultaneously, this study aims to find out the proper dose of midazolam with minimum
disturbance to patient's emergence time.