A Study of the Safety and Pharmacology of GDC-0941 in Combination With Erlotinib in Patients With Advanced Solid Tumors

• Status: Completed
• Trial end date: 2014-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This is an open-label, multicenter, Phase Ib dose-escalation study to assess the safety, tolerability, and pharmacokinetics (PK) of oral (PO) GDC-0941 administered in combination with PO erlotinib in patients with advanced solid tumors and patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) who have failed at least one prior chemotherapy regimen.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Genentech, Inc.
• Treatments: Erlotinib Hydrochloride

Criteria

Inclusion Criteria:

• Documented locally advanced or metastatic solid tumors for which standard therapy either does not exist or has proven ineffective or intolerable (dose-escalation stage only)

• Documented locally advanced or metastatic NSCLC in patients who have failed at least one prior chemotherapy-based regimen for incurable disease (cohort-expansion stage only)

• Adequate organ function as assessed by laboratory tests

• Evaluable disease or disease measurable per Response Evaluation Criteria in Solid Tumors (RECIST)

• Agreement to use an effective form of contraception for the duration of the study

Exclusion Criteria:

• Any anti-cancer therapy (e.g., chemotherapy, biologic therapy, or hormonal therapy) within a specified timeframe prior to first study treatment

• Prior treatment with PI3K pathway-inhibiting agents (cohort-expansion stage only)

• History of Grade >= 3 fasting hyperglycemia or diabetes requiring regular medication

• Current clinically significant and uncontrolled systemic disease (e.g., cardiovascular, pulmonary, or metabolic)

• History of clinically significant cardiac or pulmonary dysfunction

• History of malabsorption syndrome or other condition that would interfere with enteral absorption

• Clinically significant history of liver disease

• Any condition requiring full-dose anticoagulants, such as warfarin, heparin, or thrombolytic agents

• Active autoimmune disease and/or need for corticosteroid therapy

• Known brain metastases that are untreated, symptomatic, or require therapy

• Pregnancy, lactation, or breastfeeding