A Study of the Safety and Efficacy of Sitagliptin Addition During Metformin Up-titration (MK-0431-848)
Status:
Completed
Trial end date:
2018-02-01
Target enrollment:
Participant gender:
Summary
This trial is designed to evaluate, in adult participants with Type 2 diabetes mellitus
(T2DM) and inadequate glycemic control on sub-maximal metformin mono-therapy (1000 mg/day),
the effect of up-titration of metformin plus the addition of sitagliptin compared to
up-titration of metformin alone on glycemic control. The primary hypothesis of this study is
that up-titration of metformin to 2000 mg/day (1000 mg/twice a day) plus the addition of
sitagliptin 100 mg/day provides greater reduction in hemoglobin A1C (A1C) compared to
metformin up-titration alone. Another primary objective of this study is to evaluate the
safety and tolerability of this treatment.