Overview

A Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid Tumors

Status:
RECRUITING
Trial end date:
2030-01-01
Target enrollment:
Participant gender:
Summary
The main purpose of the study is to assess whether the study drug, LY4066434, is safe and tolerable when administered to participants with locally advanced or metastatic solid tumors with certain KRAS mutations. LY4066434 will be given alone or in combination with other treatments. The study will have 2 parts: monotherapy dose escalation and dose optimization. The study is expected to last up to approximately 5 years.
Phase:
PHASE1
Details
Lead Sponsor:
Eli Lilly and Company
Treatments:
Carboplatin
Cetuximab
Cisplatin
Fluorouracil
Gemcitabine
Irinotecan
Leucovorin
Oxaliplatin
pembrolizumab
Pemetrexed
Taxes