A Study of the Onset and Offset of Antiplatelet Effects Comparing Ticagrelor, Clopidogrel, and Placebo With Aspirin
Status:
Completed
Trial end date:
2009-03-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to see how Ticagrelor, a new oral reversible anti-platelet
medication, affects platelets. Anti-platelet agents are medications that block the formation
of blood clots by preventing the clumping of platelets. Blood clots prevent us from bleeding,
but when they form inside the arteries their formation is linked to a risk of medical
problems such as heart attack and stroke. This study investigated how long it takes for
Ticagrelor to begin working and how long it takes for it to stop working after the last dose
of drug. Ticagrelor will be compared to clopidogrel, an established anti-platelet treatment
for preventing blood clots, and placebo plus Aspirin.