A Study of the Effects of Single Dose Corticosteroids on Response to Allergens

• Status: Completed
• Trial end date: 2009-05-21
• Target enrollment: 0
• Participant gender: All

Summary

This study will investigate whether changes in inflammatory mediators produced by the nose after exposure to an allergen can be used to evaluate the anti-inflammatory effects of novel drugs for the treatment of allergic asthma.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Merck Sharp & Dohme Corp.
• Treatments: Prednisone

Criteria

Inclusion Criteria:

• Patient is allergic to Timothy grass pollen

• Female patients have a negative pregnancy test and agree to use birth control throughout the study

• Male patients agree to use birth control throughout the study

• Patient has been a nonsmoker for at least 6 months

• Patient agrees to avoid the use of aspirin and other Non-steroidal anti-inflammatory drugs (NSAIDs) throughout study

Exclusion Criteria:

• Patient is breastfeeding

• Patient has any respiratory disease other than mild stable asthma that does not require treatment

• Patient consumes more than 3 alcoholic beverages per day

• Patient consumes more than 6 caffeinated beverages per day

• Patient has had major surgery or has donated or lost 1 unit of blood within 4 weeks of screening

• Patient has severe allergies