A Study of the Effect of Dulaglutide on the Action of Warfarin in Healthy Participants
Status:
Completed
Trial end date:
2011-12-01
Target enrollment:
Participant gender:
Summary
Warfarin is a commonly used drug to prevent the blood from clotting. The purpose of this
study is to determine if dulaglutide (LY2189265) affects how warfarin works. The study
involves two different treatments (Treatment 1: warfarin; Treatment 2: dulaglutide +
warfarin) separated by a minimum washout period of 24 days. In Treatment 1, the participant
will receive 10 milligrams (mg) of warfarin on Day 1. In Treatment 2, the participant will
receive a 1.5-mg dose of dulaglutide (LY2189265) as an injection on Day 1 and then a 10 mg
dose of warfarin on Day 3. Participants will be randomly assigned into different treatment
sequences. Participants in Treatment Sequence A will receive Treatment 1 then Treatment 2.
Participants in Treatment Sequence B will receive Treatment 2 then Treatment 1.