A Study of Vonoprazan in Adults With Helicobacter Pylori
Status:
Completed
Trial end date:
2021-11-05
Target enrollment:
Participant gender:
Summary
Helicobacter Pylori (H Pylori) is a bug found in the digestive system. It can cause soreness
and redness in the stomach (gastritis). It can also cause ulcers in the stomach and other
parts of the digestive system. Vonoprazan is a medicine to treat people with H Pylori. It is
taken together with other medicines to fight infections caused by H Pylori.
The main aim of this study is to learn if vonoprazan changes how the other medicines are
processed by the body. It will be compared with another medicine called esomeprazole. Other
aims are to check for side effects from the study medicines.
At the first visit, the study doctor will check who can take part. Participants who take part
will be picked for 1 of 2 treatments by chance.
- Vonoprazan taken with bismuth, clarithromycin, and amoxicillin
- Esomeprazole taken with bismuth, clarithromycin, and amoxicillin
Both treatments will last for 14 days. Participants will stay in the clinic throughout their
treatment.
After treatment, the clinic staff will telephone the participants 2 days later for a
check-up. The participants will visit the clinic 4 weeks later for a final check-up.