A Study of Two Anti-HIV Drug Combinations in HIV-Infected Patients

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the safety and effectiveness of giving HIV-infected patients delavirdine (DLV) plus zidovudine (ZDV) plus 2 doses of indinavir (IDV) or ZDV plus IDV plus lamivudine (3TC). This study also examines how the body processes DLV when it is given in combination with other drugs.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Pharmacia and Upjohn
• Treatments: Delavirdine; Indinavir; Lamivudine; Zidovudine

Criteria

Inclusion Criteria

Patients must have:

• HIV-1 positive.

• CD4 count above 50.

• HIV-1 RNA greater than 20,000.

Prior Medication:

Allowed:

Less than 1 month prior treatment with zidovudine.

Exclusion Criteria

Prior Medication:

Excluded:

• Prior 3TC, protease inhibitors, or non-nucleoside reverse transcriptase inhibitors.

• Prior ZDV of greater than 1 month total duration.

Prior Treatment:

Excluded:

• Lamivudine.

• Protease inhibitors.

• Non-nucleoside reverse transcriptase inhibitors.