A Study of TAK-951 to Stop Adults Getting Nausea and Vomiting After Planned Surgery
Status:
Recruiting
Trial end date:
2021-11-15
Target enrollment:
Participant gender:
Summary
Some adults are at a higher risk of feeling sick (nausea) or being sick (vomiting) after they
have surgery. In this study, these adults will have planned surgery. The main aim of this
study is to learn if TAK-951 stops these adults from getting nausea or vomiting after
surgery. This will be compared with another medicine called ondansetron. Another aim is to
check for side effects from the study medicines.
Before surgery, the study doctor will check who can take part in this study. Those who can
take part will be picked for either Treatment Group A or Treatment Group B by chance.
- Treatment Group A: Just before surgery, participants will receive a placebo slowly
through a vein (infusion). Just before the end of the surgery, they will receive TAK-951
as an injection under the skin.
- Treatment Group B: Just before surgery, participants will receive ondansetron slowly
through a vein (infusion). Just before the end of the surgery, they will receive a
placebo as an injection under the skin. In this study, a placebo will look like TAK-951
but will not have any medicine in it.
Participants will not know which study medicines they received, or in which order, nor will
their study doctors or surgeons. This is to help make sure the results are more reliable.
Participants will stay in the hospital for 24 hours after their surgery so that the study
doctors can check for nausea and vomiting. The study doctors will also check for side effects
from the study medicines.
Participants will visit the hospital for a check-up 14 days later.