A Study of Spiramycin in the Treatment of Patients With AIDS-Related Diarrhea
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
To determine the safety and effectiveness of intravenous spiramycin in patients with
AIDS-related cryptosporidial diarrhea.
Spiramycin, a macrolide antibiotic, has been studied in the United States for the treatment
of cryptosporidial diarrhea. Some reports suggest that spiramycin is useful in improving the
symptoms of cryptosporidial diarrhea in some patients. Results of one study, however, showed
no significant difference between spiramycin and placebo (inactive medication). A later study
indicated that the absorption of spiramycin is significantly decreased when food is present.
Thus, the results of the trial may have been due to poor absorption of spiramycin.
Phase:
Phase 1
Details
Lead Sponsor:
Rhone-Poulenc Rorer
Collaborator:
National Institute of Allergy and Infectious Diseases (NIAID)