A Study of Pegylated Liposomal Doxorubicin and Cyclophosphamide in Her2-negative Stage I and II Breast Cancer Patients

• Status: Active, not recruiting
• Trial end date: 2023-05-01
• Target enrollment: 0
• Participant gender: Female

Summary

Primary objective:

• To evaluate the disease-free survival (DFS) in the two randomized arms after therapy with LC vs. EC in chemo-naive Her2-patients with stage I or II breast cancer

Secondary objectives:

• To assess the overall survival (OS)

• To establish the safety profile by assessing the toxicities and tolerability

• To assess the quality of life (QoL)

• To evaluate survival correlation with biomarkers expression.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: TTY Biopharm
• Treatments: Cyclophosphamide; Doxorubicin; Epirubicin; Liposomal doxorubicin

Criteria

Inclusion Criteria:

• histologically confirmed invasive, but non-inflammatory, breast adenocarcinoma with stage I or II (if N0, T must be >1cm) disease

• Her2-negative on fluorescence in situ hybridization (FISH) study

• performance status of ECOG 0, 1

• female, age between 20 and 70 years

• life expectancy of at least one year

• ability to understand and willingness to sign a written informed consent document

Exclusion Criteria:

• Her2 3+ over-expression on immunohistochemistry (IHC), or Her2 amplification on fluorescence in situ hybridization (FISH) study

• previous or current systemic malignancy with the exception of curatively treated non-melanoma skin cancer or cervical carcinoma in situ, unless there has been a disease-free interval of at least 5 years

• Patients who have received prior chemotherapy

• inadequate hematological function defined as absolute neutrophil count (ANC)less than 1,500/mm3, and platelets less than 100,000/mm3

• inadequate hepatic function defined as: serum bilirubin greater than 1.5 times the upper limit of normal range (ULN) alanine aminotransferase (ALT) or aspartate aminotransferase (AST) greater than 2.5 times the ULN

• inadequate renal function defined as serum creatinine greater than 1.5 times the ULN

• left ventricular ejection fraction (LVEF) < 50% confirmed by multiple-gated acquisition (MUGA) scan or echocardiogram

• concomitant illness that might be aggregated by chemotherapy or interfere study assessment. For examples, active, non- controlled infection (such as hepatitis B and hepatitis C, HIV, infectious tuberculosis) or other active, non-controlled disease such as congestive heart failure, ischemic heart disease, uncontrolled hypertension or arrhythmia, unstable diabetes mellitus, and active peptic ulcer

• patients who are presence of liver cirrhosis or are HBV/HCV carrier

• participation in another clinical trial with any investigational drug within 30 days prior to entry

• pregnant or breast feeding women

• fertile women of child-bearing potential unless using a reliable and appropriate contraceptive method throughout the treatment period and for three months following cessation of treatment