Overview

A Study of Oral Vismodegib for the Treatment of Idiopathic Pulmonary Fibrosis (IPF)

Status:
Withdrawn
Trial end date:
2017-01-01
Target enrollment:
0
Participant gender:
All
Summary
This is a randomized, multicenter, double-blind, placebo-controlled, parallel-group study of vismodegib in patients with IPF. Eligible patients will be randomized in a 2:1 ratio to one of two treatment arms: vismodegib or placebo. The duration of treatment will be 52 weeks. Study drug will be administered daily by the oral route. An 8-week safety follow-up period is included for all patients who receive at least one dose of study drug.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Hoffmann-La Roche
Criteria
Inclusion Criteria:

- Adult patients aged >/=40 years at Visit 1

- Diagnosis of IPF within the previous 5 years from time of screening and confirmed at
baseline

- Patients from countries where a treatment is licensed/approved for IPF must
additionally meet at least one of the following criteria to be eligible: (1) be unable
to access a licensed therapy for IPF; (2) treatment with a licensed therapy/therapies
has been stopped for lack of efficacy or because of safety/tolerability reasons (a
washout period will be required); (3) be unwilling to be treated with a licensed
therapy and study enrollment considered appropriate.

- Forced vital capacity (FVC) >/=40% and
- Stable baseline lung function as evidenced by a difference of <10% in absolute FVC
measurements (in liters) between screening and Day 1/Visit 2 prior to randomization

- Diffusion capacity of the lung for carbon dioxide (DLCO) >/=25% of predicted at
screening

- Adequate hematopoietic capacity, liver and renal function

- Female patients of childbearing potential must use two methods of acceptable
contraception, including one highly effective method and a barrier method, during
treatment and for 7 months after completion of study treatment (or as per local
requirement)

- Male patients must agree to remain abstinent or use a condom, even after a vasectomy,
during sexual intercourse with female partners while being treated with
vismodegib/placebo, and for 2 months after completion of study treatment

- Agreement not to donate blood or blood products during the study and for at least 7
months (or as per local requirements) after the last dose of study treatment

Exclusion Criteria:

- Pregnant or lactating

- Known hypersensitivity to any of the study drug excipients or the drug itself

- Prior treatment with vismodegib or any Hh-pathway inhibitor

- Evidence of other known causes of interstitial lung disease

- Hospitalization due to an exacerbation of IPF within 4 weeks prior to, or during,
screening

- Lung transplant expected within 12 months of screening

- Evidence of clinically significant lung disease other than IPF

- Substantial emphysema on high resolution computed tomography (HRCT) with degree of
emphysema greater than fibrosis

- Post bronchodilator forced expiratory volume in 1 second/FVC ratio <0.7 at screening

- Class IV New York Heart Association chronic heart failure or historical evidence of
left ventricular ejection fraction <35%

- Known current malignancy or current evaluation for a potential malignancy

- Known immunodeficiency, including but not limited to HIV infection

- Any clinically significant medical disease (other than IPF) that is associated with an
expected survival of <12 months, likely to require a change in therapy during the
study, or likely to impact the ability of the patient to participate in the study in
the opinion of the investigator, or impact the study efficacy or safety assessments