A Study of Nitazoxanide in the Treatment of AIDS-Related Diarrhea
Status:
Completed
Trial end date:
1996-02-01
Target enrollment:
Participant gender:
Summary
To determine the pharmacokinetics profile of single doses of nitazoxanide (NTZ) in patients
with AIDS-related cryptosporidial diarrhea. To determine steady state concentrations of NTZ
following repeated dosing. To assess the safety and efficacy of 4 dose levels of NTZ in these
patients.
Cryptosporidial enterocolitis in AIDS patients is frequently chronic and severe, contributing
substantially to morbidity, mortality, and health care costs in this population. NTZ exhibits
antimicrobial activity that may extend to Cryptosporidial infection.