A Study of Niaspan on Endothelium-Dependent and Endothelium-Independent Vascular Reactivity (0000-093)

• Status: Completed
• Trial end date: 2008-07-01
• Target enrollment: 0
• Participant gender: All

Summary

A study to evaluate the inter- and intra subject variabilities of flow-mediated dilation (FMD) of brachial artery and nitroglycerin (GTN) induced dilation of brachial artery.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Merck Sharp & Dohme Corp.
• Treatments: Niacin; Nicotinic Acids

Criteria

Inclusion Criteria:

• Female subjects of reproductive potential test negative for pregnancy and agree to use appropriate methods of contraception throughout the study

• Subject is in good health (other than history of high cholesterol)

• Subject is a non-smoker

Exclusion Criteria:

• Subject has a history of stroke, seizures or major neurological disorder

• Subject has a history of cancer

• Subject is unable to refrain from or anticipates the use any prescription or non-prescription drugs

• Subjects consumes excessive amounts of alcohol or caffeine