This proposed pilot study aims to assess the effects of N-acetylcysteine (NAC) on alcohol use
disorder (AUD). Despite promising preliminary research, no investigations to date have
focused on NAC with alcohol use as the primary aim or on individuals specifically seeking
treatment for AUD. The present proposal is an 7-week randomized, double-blind,
placebo-controlled study of 3000mg of NAC in up to 50 participants (25 NAC, 25 placebo).
The primary aim of the current study is to establish feasibility, dropout rate, and estimate
the standard deviation of the outcome measures in order to estimate the required sample for a
fully powered clinical trial and to refine the final measures for use in the fully powered
clinical trial. Additionally, this study will explore preliminary efficacy signal of NAC.
Phase:
Phase 2
Details
Lead Sponsor:
Uniformed Services University of the Health Sciences