Overview

A Study of LY3457263 Alone and in Combination With Dulaglutide (LY2189265) in Participants With Type 2 Diabetes

Status:
Not yet recruiting
Trial end date:
2023-09-22
Target enrollment:
0
Participant gender:
All
Summary
The main purpose of this study is to investigate the safety and tolerability of the study drug LY3457263 when administered alone or in combination with glucagon-like peptide 1 (GLP-1) receptor agonist (RA) in participants with type 2 diabetes. Blood tests will be performed to investigate how the body processes the study drug and how the study drug affects the body. The study will last up to approximately 16 weeks excluding the screening period for each participant and include up to 17 visits.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Eli Lilly and Company
Treatments:
Dulaglutide
Criteria
Inclusion Criteria:

- Participants with type 2 diabetes (T2D) at least 6 months before screening

- Participants treated for T2D with diet and exercise, with or without metformin

- Have a glycated hemoglobin A1c (HbA1c) value of ≥ 7.5% and ≤10.5%

- Have had a stable body weight for 3 months and body mass index (BMI) of 27.0 to 45.0
kilograms per meter squared (kg/m²)

- Male participants who agree to use effective methods of contraception and female
participants not of childbearing potential

Exclusion Criteria:

- Have a history of or current cardiovascular, respiratory, hepatic, renal, GI,
endocrine (apart from T2D), hematological, or neurological disorders capable of
altering the absorption, metabolism, or elimination of drugs

- Have type 1 diabetes mellitus or latent autoimmune diabetes in adults or
maturity-onset diabetes of the young

- Have a history of proliferative diabetic retinopathy, diabetic maculopathy, or severe
non-proliferative diabetic retinopathy

- Have known allergies to GLP-1 receptor agonists