A Study of Intraventricular Liposomal Encapsulated Ara-C (DepoCyt) in Patients With Recurrent Glioblastoma
Status:
Terminated
Trial end date:
2014-09-01
Target enrollment:
Participant gender:
Summary
Current treatments for Glioblastoma Multiforme (GBM), the most common and malignant primary
brain tumor are inadequate and as such, the median survival for most patients with GBM is on
the order of months, even after cytoreductive surgery, radiation and chemotherapy. This study
aims to develop a new treatment for GBM by suppressing glial progenitor cells that surround
the ventricular system in patients with these aggressive tumors because it is these regions
that appear to act as an incubator for future recurrences resulting in patient death.
Considering the lack of significant treatment options for patients with this uniformly fatal
disease, this is an important translational clinical study to perform.