A Study of Intravenous Thrombolysis With Alteplase in MRI-Selected Patients
Status:
Completed
Trial end date:
2016-05-01
Target enrollment:
Participant gender:
Summary
This study was jointly developed and is jointly led by investigators at Massachusetts General
Hospital and the intramural division of NINDS. We are doing this research study to find out
if Activase ® (also called alteplase or rt-PA) can safely be given to people with an acute
ischemic stroke when their stroke onset was not witnessed making them ineligible for standard
thrombolytic (clot busting) therapy. We also want to find out if rt-PA can help people
recover better from their stroke.
The purpose of this study is to: 1) see if it is safe to give intravenous (IV) rt-PA to
people with unwitnessed stroke but with MRI evidence of early ischemic stroke, 2) see if
rt-PA is effective if given to people who are selected for treatment based on MRI evidence of
an early stroke, and 3) get information about this new MRI diagnostic methods for guiding
stroke treatment.
Phase:
Phase 2
Details
Lead Sponsor:
Lee Schwamm
Collaborators:
Genentech, Inc. National Institute of Neurological Disorders and Stroke (NINDS)