A Study of Intravenous Acetaminophen for Small Bowel Obstruction

• Status: Not yet recruiting
• Trial end date: 2023-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare IV Acetaminophen for pain control to the usual care with opioids in patients admitted for small bowel obstruction.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mayo Clinic
• Treatments: Acetaminophen

Criteria

Inclusion Criteria:

• Small bowel obstruction diagnosed by radiographic study; and

• Abdominal pain on admission.

• Nothing per mouth diet.

• The ability to give appropriate consent or have an appropriate representative available to do so.

Exclusion Criteria:

• Known liver failure or cirrhosis.

• Acetaminophen toxicity on admission.

• Known acetaminophen allergy.

• Alcohol intoxication on admission.

• History of substance abuse.

• Creatinine clearance < 30 (or Creatinine level > 2).

• Liver transplant recipients.

• Ileus on admission.

• Admitted for surgical intervention for SBO.

• Admitted for venting Gastric tube placement.

• On chronic opioid therapy (defined as use of opioid on daily or near daily basis within previous 45 days (both long acting and short acting).

• Presentation without abdominal pain on admission.

• Already hospitalized for other reasons and develop SBO while at the hospital.

• Pregnant women.

• Unable to provide informed consent.