A Study of Intra-Ophthalmic Artery Topotecan Infusion for the Treatment of Retinoblastoma
Status:
Terminated
Trial end date:
2015-10-01
Target enrollment:
Participant gender:
Summary
This study will test if giving topotecan directly into the blood vessel of the eye will
improve the treatment of retinoblastoma. This method is referred to as "selective
intra-ophthalmic artery chemotherapy" (SIOAC).
The goals of this study are:
- To find out if topotecan is an effective treatment for retinoblastoma when delivered
directly to the ophthalmic artery (SIOAC delivery)
- To find out what kind of effects (good and bad) can be expected when topotecan is given
by SIOAC
- To assess visual pathway function before and after the study therapy
- To learn more about the pharmacology (how your body handles the drug) of topotecan when
delivered directly to the ophthalmic artery