Objectives:
1. To study the effect of anti-angiogenesis therapy on reducing the recurrence of high-risk
oral cavity cancer patients after curative local treatment.
2. To study the toxicity and compliance of post-operative anti-angiogenesis therapy
Study design:
This is a multi-center randomized controlled phase II/III two-stage study.
Study endpoints:
The primary endpoint is the tumor-free survival (primary and second primary malignancies) and
the primary analysis is to compare the tumor-free survival between groups.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
National Health Research Institutes, Taiwan
Collaborators:
Buddhist Tzu Chi General Hospital Chang Gung Memorial Hospital Changhua Christian Hospital Chi Mei Medical Hospital Kaohsiung Veterans General Hospital. Mackay Memorial Hospital National Cheng-Kung University Hospital National Taiwan University Hospital Sun Yat-sen University