A Study of HS-196, an HSP90 Inhibitor-linked NIR Probe for Solid Malignancies
Status:
Recruiting
Trial end date:
2023-08-10
Target enrollment:
Participant gender:
Summary
HS-196 is near infrared red (NIR)-tethered HSP90 inhibitor for clinical imaging of selective
tumor binding. HS-196 consists of a HSP90 inhibitor that binds competitively to the Hsp90 ATP
binding domain connected by a linker to a contrast agent (near infrared (NIR) dye) that can
be used for imaging. HS-196 can freely enter tumor cells to selectively bind Hsp90. Due to
the the NIR dye, HS-196 accumulation in the malignant cells allows for specific visualization
of tumors within the body.