A Study of Famitinib in Patients With Advanced Metastatic Renal Cell Cancer

• Status: Completed
• Trial end date: 2016-05-01
• Target enrollment: 0
• Participant gender: All

Summary

• Famitinib is a tyrosin-inhibitor agent targeting at c-Kit, VEGFR2, PDGFR, VEGFR3, Flt1 and Flt3. Phase I study has shown that the toxicity is manageable.

• The purpose of this study is to compare the efficacy and safety profile between Famitinib and Sunitinib in patients with metastatic renal cell carcinoma.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Jiangsu HengRui Medicine Co., Ltd.
• Collaborator: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
• Treatments: Sunitinib

Criteria

Inclusion Criteria:

• Patients with histologically confirmed advanced renal cell carcinoma including clear cell component and not available for surgery

• First-line therapy or second-line treatment (second-line treatment e.g chemotherapy or cytokine therapy as first-line treatment failure or resistant patients)

• With measurable disease (using RECIST1.0 standard conventional CT scan ≥ 20 mm, spiral CT scan ≥ 10mm, target lesion did not receive radiation therapy, cryotherapy)

• Male or female, age ≥18 and ≤75

• ECOG 0-1

• Life expectancy ≥ 3 months

• Subjects received surgery, chemotherapy, radiation therapy, cytokines treatment caused the damage has been restored, the time interval ≥ 4 weeks, and the wound has completely healed

• Normal major organ function

• Signed and dated informed consent

Exclusion Criteria:

• Previously received targeted therapy of the metastatic renal cell carcinoma (such as sunitinib, Sorafenib)

• Past or suffering from other cancer, but other than cure basal cell carcinoma and cervical carcinoma in situ

• Participated in other clinical trials within four weeks

• A variety of factors that affect the oral medication (such as inability to swallow, gastrointestinal resection, chronic diarrhea and intestinal obstruction)

• Known brain metastases, spinal cord compression, cancer, meningitis, or screening CT or MRI examination revealed brain or leptomeningeal disease

• Patients with hypertension (systolic blood pressure> 140 mmHg, diastolic blood pressure> 90 mmHg). Patients with more than Class I, myocardial ischemia or myocardial infarction, arrhythmia (including QT interval ≥ 440ms) and class I heart failure.

• Urine protein ≥ + + and confirmed the 24-hour urinary protein>1.0 g

• Coagulopathy with bleeding tendency (such as active peptic ulcer) or are receiving thrombolytic or anticoagulant therapy

• Previous hyperactivity / venous thromboembolic events, such as cerebrovascular accident (including transient ischemic attacks), deep vein thrombosis and pulmonary embolism

• The preexisting abnormal thyroid function, even in the case of medication still can not be maintained within the normal range

• With a history of abuse of psychotropic drugs or mental disorders

• Patients with Hepatitis B or Hepatitis C

• History of immunodeficiency, including HIV testing positive or suffering from acquired, congenital immunodeficiency disease, or a history of organ transplantation