Overview A Study of Different Titration Schedules of ALKS 5461 in Adults With Major Depressive Disorder (MDD) Status: Completed Trial end date: 2014-09-01 Target enrollment: Participant gender: Summary This is a Phase 3 study designed to evaluate the safety and tolerability of two titration schedules for ALKS 5461. Phase: Phase 3 Details Lead Sponsor: Alkermes, Inc.