A Study of Dexmedetomidine Pharmacokinetics for Preoperative Sedation
Status:
Completed
Trial end date:
2020-01-23
Target enrollment:
Participant gender:
Summary
Proper preoperative sedation can reduce patients' anxiety, enhance patients' cooperation and
reduce perioperative complications. The investigators would explore the sedative effects of
dexmedetomidine (DEX) with the administration of oral, intravenous and nasal drops, and
detect DEX blood concentration in 15 participants, respectively. Pharmacokinetic parameters
are detected at 8 time points ( before DEX administration, 10 min, 20 min, 30 min, 45 min,
60min, 90min and 120 min after administration). 3 ml arterial blood was collected at each
time point. The blood samples are detected by mass spectrometer. The aim of this study is to
investigate appropriate administration time and route for DEX sedation.