A Study of Co-infections of HIV-1 and Schistosoma Mansoni and Its Impact on Praziquantel Treatment Outcomes
Status:
Unknown status
Trial end date:
2013-06-01
Target enrollment:
Participant gender:
Summary
In this study, it is hypothesized that helminth infections modulate immune responses against
HIV-1 infection resulting into increased HIV-1 multiplication, faster progression to AIDS and
increased episodes of AIDS-related opportunistic infections. Furthermore, the effect of
helminth infections on progression of HIV-1 infection is dependent on helminth infection
intensity, host background immunity, nutritional status, demographic factors and
socio-economic status. Also, treatment of helminth infections using praziquantel and
albendazole among HIV-1 infected individuals will lead to reduction in HIV-1 viral loads,
improvement of CD4+ counts, CD4+/CD8+ ratio and Hb levels, improved weight gain and reduction
of episodes of HIV-1 related opportunistic infections. In addition, HIV-1 infection is
associated with poor anthelminthic treatment outcome as compared to non-HIV infected
individuals
Phase:
N/A
Details
Lead Sponsor:
Catholic University of Health and Allied Sciences
Collaborators:
National Institute for Medical Research, Tanzania University of Cambridge