A Study of Azithromycin Plus Pyrimethamine in the Treatment of a Brain Infection in Patients With AIDS
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
To evaluate the effectiveness and toxicity of oral azithromycin and pyrimethamine as acute
therapy for toxoplasmic encephalitis in AIDS patients. To assess the toxicity and
effectiveness of azithromycin alone as maintenance therapy.
Encephalitis caused by Toxoplasma gondii is the most frequent cause of focal central nervous
system infection in patients with AIDS. Untreated, the encephalitis is fatal. Standard
treatment for toxoplasmic encephalitis is associated with serious adverse effects. Thus,
alternative treatments are needed.
Phase:
Phase 1
Details
Lead Sponsor:
Pfizer
Collaborator:
National Institute of Allergy and Infectious Diseases (NIAID)