A Study of Aprepitant (MK-0869) in Pediatric Participants Undergoing Surgery (MK-0869-148)
Status:
Completed
Trial end date:
2013-03-12
Target enrollment:
Participant gender:
Summary
This two part study will determine the appropriate dosing regimen of aprepitant for the
prevention of postoperative nausea and vomiting (PONV) in pediatric participants 6 months to
17 years of age, by assessing pharmacokinetic parameters and monitoring safety and
tolerability of administered doses. Part I will be an open label investigation of a single
dose of aprepitant measuring pharmacokinetics at specified time points up to 48 hours after
aprepitant dosing. Part II will be a double blind trial of participants randomized to receive
either aprepitant or ondansetron.