A Study of Alendronate Sodium Vitamin D3 Tablets on Knee Osteoarthritis

• Status: Not yet recruiting
• Trial end date: 2024-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the effect of alendronate sodium vitamin D3 tablets compared with placebo on the improvement of joint structure and joint pain in participants with knee osteoarthritis. The treatment period of this study is one year and followed-up period is 2 years. The results of knee joint MRI will be evaluated by using the WORMS score.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking Union Medical College Hospital
• Collaborator: CSPC Ouyi Pharmaceutical Co., Ltd.
• Treatments: Alendronate; Cholecalciferol; Vitamin D

Criteria

Inclusion Criteria:

1. Patients with significant knee pain (pain score≥40mm on the 100mmVAS scale);

2. Male or female patients, between 50-75 years old;

3. MRI suggests bone marrow edema-like lesions;

4. Knee osteoarthritis (in accordance with the diagnostic criteria of American College of Rheumatology (ACR) and Chinese Orthopaedic Association);

5. Kellgren-Lawrence gradingⅠorⅡin X-ray;

Exclusion Criteria:

1. Other forms of active arthritis (such as rheumatoid arthritis or other inflammatory arthritis);

2. Taken non-steroidal anti-inflammatory drugs and central analgesics (such as opioids) within two weeks；

3. Liver function ALT or AST is 1.5 times the upper limit of normal； creatinine clearance <35ml/min；

4. Pregnancy or suckling;

5. Serious heart disease, endocrine, digestive, mental, nervous system diseases or cancer;

6. Active ulcers and a history of upper gastrointestinal bleeding;

7. Esophageal motility disorders, such as esophageal tardiness or stenosis;

8. Renal dysfunction or osteomalacia;

9. Tobacco addiction (mean 10 cigarettes per day or more) or/and alcohol addiction (mean 50ml per day or more);

10. Fresh fracture in the last six months;

11. Serious illnesses and life expectancy<2 years;

12. Allergic to study drugs;

13. Used any study drug or device within 30 days before randomization or within the drug half-life (whichever is longer);

14. Failure to take medication as required;

15. Replacement surgery in the near future;

16. Contraindications to MRI scans (e.g. implanted pacemakers, metal sutures, shrapnel or iron filings in the eyes, claustrophobia, knees too large to use coils);

17. Sensitive to or unsuitable for X-ray exposure (e.g. aplastic anemia, etc);

18. Poor dental health or dental surgery in the near future.