Overview A Study of ALKS 5461 for Treatment Refractory Major Depressive Disorder (MDD) Status: Completed Trial end date: 2020-03-05 Target enrollment: Participant gender: Summary This study will evaluate the efficacy, safety, and tolerability of adjunctive ALKS 5461 in adults who have treatment refractory MDD. Phase: Phase 3 Details Lead Sponsor: Alkermes, Inc.Treatments: BuprenorphineNaltrexone